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Sleep: the golden chain for mental health

World Sleep Day aims to celebrate sleep and raise awareness of how sleep problems impact on society.

Mae’r cynnwys hwn ar gael yn Saesneg yn unig.

Celebrating sleep

Extolling the virtues of sleep is not a modern phenomenon. Over 400 years ago, Thomas Dekker dedicated a chapter of his 1609 work, The Guls Horne-booke, to ‘The praise of sleep and of going naked’.

Dekker’s musings on nakedness are another matter, however, he aptly described sleep as ‘that golden chain that ties health and our bodies together’ noting that ‘too little tumbles us into a Church-yard, and to use it but indifferently, throws us into Bedlam’.

sleeping cat

Much scientific research has since shown that sleep is crucial for physical and mental well being, affecting multiple processes in our bodies from memory to metabolism. My research focuses on how sleep affects mental health.

Sleep problems as a symptom of mental ill-health

In the 19th century, Emil Kraepelin, considered the grandfather of modern psychiatry, noted that sleep disturbances were common in patients with psychiatric disorders and recommended treatments that promoted sleep.

Today, the diagnostic systems used in research and clinical practice mirror Kraepelin’s observations. For example, the fifth version of the Diagnostic and Statistical Manual of Mental Disorders includes sleep disturbance as a symptom of bipolar disorder, major depressive disorder and anxiety disorders.

arm sticking out from under duvet

However, the question of whether poor sleep ‘throws us into Bedlam’ (i.e. causes mental ill-health) has received relatively little attention until more recently.

Does sleep loss ‘throw us into Bedlam’?

There has been a growing interest in whether sleep problems can be a cause as well as a symptom of mental illness.

For example, epidemiological studies suggest that people with insomnia are at a greater risk of developing disorders such as depression and anxiety, and periods of sleep deprivation have been followed by manic episodes in people with bipolar disorder.

These associations have been supported by evidence from experimental studies. For example, Gessa and colleagues reported that rats displayed manic-like behaviours following sleep deprivation and other studies have found sleep deprivation in humans to lead to deficits in emotion processing and psychosis-like symptoms.

Implications for clinical practice

Understanding more about how sleep problems influence the course of psychiatric disorders could greatly facilitate efforts to treat mental ill-health.

For example, interventions that aim to improve sleep have been associated with improving symptoms of depression, reducing the risk of relapse in bipolar disorder, and reducing paranoia and hallucinatory experiences.

A complex relationship

In spite of considerable progress in this area of research, there is still much more we need to investigate about the relationship between sleep and mental health.

First, psychiatric illnesses are complex and caused by a variety of genetic and environmental factors, therefore poor sleep may not be a risk factor for everyone.

For example, in a study of over 3,000 people with bipolar disorder, we found that 20% of participants reported that sleep loss had triggered episodes of high mood, with women more likely to report this than men.

man sat in dark lit by screen

Second, our sleep patterns are influenced by numerous factors which further complicate attempts to understand the relationship between poor sleep and mental health. One influence, highlighted in the 2017 Nobel prize awards, is our circadian rhythms (24-hour rhythms in our physiology and behaviour). These rhythms influence the sleep-wake cycle and are affected by factors such as light exposure, behaviour and genetic variation.

Our research

At the National Centre for Mental Health and MRC Centre for Neuropsychiatric Genetics and Genomics, we are exploring the relationship between sleep and mental health using a variety of methods.

For example, we are using genetic data from a study of over 6,000 people with bipolar disorder to investigate whether genetic risk for sleep problems is associated with different features of bipolar disorder.

We are also exploring the long-term relationships between sleep and mood using activity monitors and daily diaries.

NCMH sleep diary

NCMH Sleep Diary


The relationship between sleep and mental health is complex, therefore progress in this area requires researchers to consider the influence of behaviour, biology and environment.

Such complexities make unravelling the links in the ‘golden chain’ a challenging but exciting area of research that could ultimately aid the understanding and treatment of psychiatric disorders.

If Dekker were alive, he might be pleased to hear that his writings on sleep (if not nakedness) are still relevant today.

Find out more about how you can take part in our sleep research.

We also run workshops on the science of sleep which are advertised through our Facebook page.

Read more

Dr Katie Lewis

Mae Katie yn ymchwilio i anhwylder deubegwn a chwsg yng Nghanolfan MRC ar gyfer Geneteg Niwroseiciatrig a Genomeg ym Mhrifysgol Caerdydd.

Gofrestru ar gyfer y cylchlythyr

Y Ganolfan Iechyd Meddwl Genedlaethol,
Prifysgol Caerdydd,
Adeilad Hadyn Ellis,
Heol Maindy,
CF24 4HQ

+44 (0)29 2068 8401
Mae’r NCMH yn rhan o’r isadeiledd ymchwil i Gymru a ariannir gan Ymchwil lechyd a Gofal Cymru. | Polisi preifatrwydd